Infectious Diseases

 

Infectious Agents

We have seen that the entire diversity seen in the living world can be classified into a few groups. This classification is based on common characteristics between different organisms. Organisms that can cause disease are found in a wide range of such categories of classification. Some of them are viruses, some are bacteria, some are fungi, some are single-celled animals or protozoans. Some diseases are also caused by multicellular organisms, such as worms of different kinds.

 

Fig.1.

  

 

Fig.2. Picture of staphylococci, the bacteria which can cause acne.

The scale of the image is indicated by the line at top left, which is 5 micrometres long.

 

Fig.3. Picture of Trypanosoma, the protozoan organism responsible for sleeping sickness.

The organism is lying next to a saucer-shaped red blood cell to give an idea of the scale.
Copyright: Oregon Health and Science University, U.S.

 

Fig.4.Picture of Leishmania, the protozoan organism that causes kala-azar.

The organisms are oval-shaped, and each has one long whip-like structure. One organism (arrow) is dividing, while a cell of the immune system (lower right) has gripped on the two whips of the dividing organism and is sending cell processes up to eat up the organism. The immune cell is about ten micrometres in diameter.

 

Fig.5.Picture of an adult roundworm (Ascaris lumbricoides is the technical name) from the small intestine.

The ruler next to it shows four centimetres to give us an idea of the scale.

 

Common examples of diseases caused by viruses are the common cold, influenza, dengue fever and AIDS. Diseases like typhoid fever, cholera, tuberculosis and anthrax are caused by bacteria. Many common skin infections are caused by different kinds of fungi. Protozoan microbes cause many familiar diseases, such as malaria and kalaazar. All of us have also come across intestinal worm infections, as well as diseases like elephantiasis caused by diffferent species of worms.

Why is it important that we think of these categories of infectious agents?

The answer is that these categories are important factors in deciding what kind of treatment to use. Members of each one of these groups – viruses, bacteria, and so on – have many biological characteristics in common.

All viruses, for example, live inside host cells, whereas bacteria very rarely do. Viruses, bacteria and fungi multiply very quickly, while worms multiply very slowly in comparison. Taxonomically, all bacteria are closely related to each other than to viruses and vice versa. This means that many important life processes are similar in the bacteria group but are not shared with the virus group. As a result, drugs that block one of these life processes in one member of the group is likely to be effective against many other members of the group. But the same drug will not work against a microbe belonging to a different group.

As an example, let us take antibiotics. They commonly block biochemical pathways important for bacteria. Many bacteria, for example, make a cell-wall to protect themselves. The antibiotic penicillin blocks the bacterial processes that build the cellwall. As a result, the growing bacteria become unable to make cell-walls, and die easily. Human cells don’t make a cell-wall anyway, so penicillin cannot have such an effect on us. Penicillin will have this effect on any bacteria that use such processes for making cell-walls. Similarly, many antibiotics work against many species of bacteria rather than simply working against one.

But viruses do not use these pathways at all, and that is the reason why antibiotics do not work against viral infections. If we have a common cold, taking antibiotics does not reduce the severity or the duration of the disease. However, if we also get a bacterial infection along with the viral cold, taking antibiotics will help. Even then, the antibiotic will work only against the bacterial part of the infection, not the viral infection.

 

Means of Spread

How do infectious diseases spread?

Many microbial agents can commonly move from an affected person to someone else in a variety of ways. In other words, they can be ‘communicated’, and so are also called communicable diseases.

Such disease-causing microbes can spread through the air. This occurs through the little droplets thrown out by an infected person who sneezes or coughs. Someone standing close by can breathe in these droplets, and the microbes get a chance to start a new infection. Examples of such diseases spread through the air are the common cold, pneumonia and tuberculosis.

We all have had the experience of sitting near someone suffering from a cold and catching it ourselves. Obviously, the more crowded our living conditions are, the more likely it is that such airborne diseases will spread.

 

Fig.5.

 

Diseases can also be spread through water. This occurs if the excreta from someone suffering from an infectious gut disease, such as cholera, get mixed with the drinking water used by people living nearby. The cholera causing microbes will enter new hosts through the water they drink and cause disease in them. Such diseases are much more likely to spread in the absence of safe supplies of drinking water.

The sexual act is one of the closest physical contact two people can have with each other. Not surprisingly, there are microbial diseases such as syphilis or AIDS that are transmitted by sexual contact from one partner to the other. However, such sexually transmitted diseases are not spread by casual physical contact. Casual physical contacts include handshakes or hugs or sports, like wrestling, or by any of the other ways in which we touch each other socially. Other than the sexual contact, the AIDS virus can also spread through blood-to-blood contact with infected people or from an infected mother to her baby during pregnancy or through breast feeding.

We live in an environment that is full of many other creatures apart from us. It is inevitable that many diseases will be transmitted by other animals. These animals carry the infecting agents from a sick person to another potential host. These animals are thus the intermediaries and are called vectors. The commonest vectors we all know are mosquitoes. In many species of mosquitoes, the females need highly nutritious food in the form of blood in order to be able to lay mature eggs. Mosquitoes feed on many warm-blooded animals, including us. In this way, they can transfer diseases from person to person.

 

Organ Specific and Tissue Specific Manifestations

The disease-causing microbes enter the body through these different means. Where do they go then? The body is very large when compared to the microbes. So there are many possible places, organs or tissues, where they could go. Do all microbes go to the same tissue or organ, or do they go to different ones?

Different species of microbes seem to have evolved to home in on different parts of the body. In part, this selection is connected to their point of entry. If they enter from the air via the nose, they are likely to go to the lungs.This is seen in the bacteria causing tuberculosis. If they enter through the mouth, they can stay in the gut lining like typhoidcausing bacteria. Or they can go to the liver, like the viruses that cause jaundice.

But this needn’t always be the case. An infection like HIV, that comes into the body via the sexual organs, will spread to lymph nodes all over the body. Malaria-causing microbes, entering through a mosquito bite, will go to the liver, and then to the red blood cells. The virus causing Japanese encephalitis, or brain fever, will similarly enter through a mosquito bite. But it goes on to infect the brain.

The signs and symptoms of a disease will thus depend on the tissue or organ which the microbe targets. If the lungs are the targets, then symptoms will be cough and breathlessness. If the liver is targeted, there will be jaundice. If the brain is the target, we will observe headaches, vomiting, fits or unconsciousness. We can imagine what the symptoms and signs of an infection will be if we know what the target tissue or organ is, and the functions that are carried out by this tissue or organ.

In addition to these tissue-specific effects of infectious disease, there will be other common effects too. Most of these common effects depend on the fact that the body’s immune system is activated in response to infection. An active immune system recruits many cells to the affected tissue to kill off the disease-causing microbes. This recruitment process is called inflammation. As a part of this process, there are local effects such a swelling and pain, and general effects such as fever.

In some cases, the tissue-specificity of the infection leads to very general-seeming effects. For example, in HIV infection, the virus goes to the immune system and damages its function. Thus, many of the effects of HIV-AIDS are because the body can no longer fight off the many minor infections that we face everyday. Instead, every small cold can become pneumonia. Similarly, a minor gut infection can produce major diarrhoea with blood loss. Ultimately, it is these other infections that kill people suffering from HIV-AIDS.

It is also important to remember that the severity of disease manifestations depend on the number of microbes in the body. If the number of microbes is very small, the disease manifestations may be minor or unnoticed. But if the number is of the same microbe large, the disease can be severe enough to be life-threatening. The immune system is a major factor that determines the number of microbes surviving in the body. We shall look into this aspect a little later in the chapter.

 

Principles of Treatment

What are the steps taken by your family when you fall sick? Have you ever thought why you sometimes feel better if you sleep for some time? When does the treatment involve medicines?

Based on what we have learnt so far, it would appear that there are two ways to treat an infectious disease. One would be to reduce the effects of the disease and the other to kill the cause of the disease. For the first, we can provide treatment that will reduce the symptoms. The symptoms are usually because of inflammation. For example, we can take medicines that bring down fever, reduce pain or loose motions. We can take bed rest so that we can conserve our energy. This will enable us to have more of it available to focus on healing.

But this kind of symptom-directed treatment by itself will not make the infecting microbe go away and the disease will not be cured. For that, we need to be able to kill off the microbes.

How do we kill microbes?

One way is to use medicines that kill microbes. We have seen earlier that microbes can be classified into different categories. They are viruses, bacteria, fungi or protozoa. Each of these groups of organisms will have some essential biochemical life process which is peculiar to that group and not shared with the other groups. These processes may be pathways for the synthesis of new substances or respiration.

These pathways will not be used by us either. For example, our cells may make new substances by a mechanism different from that used by bacteria. We have to find a drug that blocks the bacterial synthesis pathway without affecting our own. This is what is achieved by the antibiotics that we are all familiar with. Similarly, there are drugs that kill protozoa such as the malarial parasite.

One reason why making anti-viral medicines is harder than making antibacterial medicines is that viruses have few biochemical mechanisms of their own. They enter our cells and use our machinery for their life processes. This means that there are relatively few virus-specific targets to aim at. Despite this limitation, there are now effective anti-viral drugs, for example, the drugs that keep HIV infection under control.

 

Principles of Prevention

All of what we have talked about so far deals with how to get rid of an infection in someone who has the disease. But there are three limitations of this approach to dealing with infectious disease. The first is that once someone has a disease, their body functions are damaged and may never recover completely. The second is that treatment will take time, which means that someone suffering from a disease is likely to be bedridden for some time even if we can give proper treatment. The third is that the person suffering from an infectious disease can serve as the source from where the infection may spread to other people. This leads to the multiplication of the above difficulties. It is because of such reasons that prevention of diseases is better than their cure.

How can we prevent diseases?

There are two ways, one general and one specific to each disease. The general ways of preventing infections mostly relate to preventing exposure.

How can we prevent exposure to infectious microbes?

If we look at the means of their spreading,we can get some easy answers. For airborne microbes, we can prevent exposure by
providing living conditions that are not overcrowded. For water-borne microbes, we can prevent exposure by providing safe drinking water. This can be done by treating the water to kill any microbial contamination. For vector-borne infections, we can provide clean environments. This would not, for example, allow mosquito breeding. In other words, public hygiene is one basic key to the prevention of infectious diseases.

In addition to these issues that relate to the environment, there are some other general principles to prevent infectious diseases. To appreciate those principles, let us ask a question we have not looked at so far. Normally, we are faced with infections everyday. If someone is suffering from a cold and cough in the class, it is likely that the children sitting around will be exposed to the infection. But all of them do not actually suffer from the disease. Why not?

This is because the immune system of our body is normally fighting off microbes. We have cells that specialise in killing infecting microbes. These cells go into action each time infecting microbes enter the body. If they are successful, we do not actually come down with any disease. The immune cells manage to kill off the infection long before it assumes major proportions. As we noted earlier, if the number of the infecting microbes is controlled, the manifestations of disease will be minor. In other words, becoming exposed to or infected with an infectious microbe does not necessarily mean developing noticeable disease.

So, one way of looking at severe infectious diseases is that it represents a lack of success of the immune system. The functioning of the immune system, like any other system in our body, will not be good if proper and sufficient nourishment and food is not available. Therefore, the second basic principle of prevention of infectious disease is the availability of proper and sufficient food for everyone.

These are the general ways of preventing infections. What are the specific ways?

They relate to a peculiar property of the immune system that usually fights off microbial infections. Let us cite an example to try and
understand this property.

But as recently as a hundred years ago, smallpox epidemics were not at all uncommon. In such an epidemic,people used to be very afraid of coming near someone suffering from the disease since they were afraid of catching the disease.However, there was one group of people who did not have this fear. This was a group of people who had had smallpox earlier and survived it, although with a lot of scarring. In other words, if you had smallpox once, there was no chance of suffering from it again. So, having the disease once was a means of preventing subsequent attacks of the same disease.

This happens because when the immune system first sees an infectious microbe, it responds against it and then remembers it specifically. So the next time that particular microbe, or its close relatives enter the body, the immune system responds with even greater vigour. This eliminates the infection even more quickly than the first time around. This is the basis of the principle of vaccination’ has come into our usage.We can now see that, as a general principle, we can ‘fool’ the immune system into developing a memory for a particular infection by putting something, that mimics the microbe we want to vaccinate against, into the body. This does not actually cause the disease but this would prevent any subsequent exposure to the infecting microbe from turning into actual disease.Many such vaccines are now available for preventing a whole range of infectious diseases, and provide a disease-specific means of prevention.

There are vaccines against tetanus, diphtheria, whooping cough, measles, polio and many others.Some hepatitis viruses, which cause jaundice, are transmitted through water. There is a vaccine for one of them, hepatitis A, in the market. But the majority of children in many parts of India are already immune to hepatitis A by the time they are five years old. This is because they are exposed to the virus through water.

Famously, two centuries ago, an English physician named Edward Jenner, realised that milkmaids who had had cowpox did not catch smallpox even during epidemics. Cowpox is a very mild disease. Jenner tried deliberately giving cowpox to people , and found that they were now resistant to smallpox. This was because the smallpox virus is closely related to the cowpox virus.  ‘Cow’ is ‘vacca’ in Latin, and cowpox is ‘vaccinia’. From these roots, the word.

 

What you have learnt?

1. Disease may be due to infectious or non-infectious causes.

2. Infectious agents belong to different categories of organisms and may be unicellular and microscopic or multicellular.

3. The category to which a disease-causing organism belongs decides the type of treatment.

4.  Infectious agents are spread through air, water, physical contact or vectors.

5. Prevention of disease is more desirable than its successful treatment.

6.  Infectious diseases can be prevented by public health hygiene measures that reduce exposure to infectious agents.

7. Infectious diseases can also be prevented by using immunisation.

8. Effective prevention of infectious diseases in the community requires that everyone should have access to public hygiene and immunisation.